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Faculty Profile Last Modified Time: 11:13:15 AM Mon, 30 Mar 2020   Contact Information John Allen Associated Profiles  Assistant Professor, Pharmacology & Toxicology, UT Medical Branch at Galveston     joaallen@utmb.edu     (409) 772-9621    Web Link    Neuropharmacology, Drug Discovery and Translational Research for Neurological and Psychiatric Disorders, Cell Biology, Biochemistry and Pharmacology of G Protein-Coupled Receptors    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Physiology and Biophysics University of Illinois-School of Medicine 2008  BS Cell Biology University of Illinois 2002  Research and Expertise Research Interests   The main emphasis of the research in the laboratory is to understand the signal transduction of G protein-coupled receptors (GPCRs) and to identify and advance GPCR targeted molecules for therapeutic drug discovery. GPCRs are the largest group of signaling proteins in the human genome and an estimated 30-40% of all marketed drugs act directly to modulate this receptor family. Our primary focus is the neuropharmacology of dopamine, serotonin and other GPCRs that control the striatum and basal ganglia neuronal system. GPCRs within the striatum mediate reward behavior and movement coordination underlying not only addictive effects of abused drugs such as cocaine but also dysfunctions observed in movement disorders such as Parkinson's and Huntington's disease. We apply a synergistic approach using cell/molecular, biochemical and systems pharmacology to reveal the mechanisms of GPCR signaling in cells, neurons and in the brain. We also apply large scale screening technologies to identify novel GPCR ligands and test compounds for their therapeutic potential in rodent models of addiction and related neuropsychiatric diseases.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Mental Health Research Cluster  University of Texas Medical Branch Center for Addiction Research Department of Pharmacology and Toxicology  Appointments Title Department / School Institution Assistant Professor Department of Pharmacology and Toxicology University of Texas Medical Branch

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