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Faculty Profile Last Modified Time: 08:37:17 AM Mon, 30 Mar 2020   Contact Information Alan Swann Associated Profiles  Professor, Psychiatry & Behavioral Sciences, Baylor College of Medicine     1977 Butler Blvd., 4th floor, Houston, TX 77030     Jamail Specialty Care Center (Clinic)    alan.swann@bcm.edu     (713) 798-6379    Web Link    Affective Disorders Bipolar disorder Depression and mood disorders Substance Use Disorders    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD   UT Southwestern Medical School 1972  Research and Expertise Research Interests   I have conducted extensive research combining clinical, neurophysiological, pharmacological, and human laboratory strategies to understand roles of impulsivity and catecholamine function in addictive disorders, cluster B personality disorders, and all phases of bipolar disorder, including the role of impulsivity in interactions between bipolar and addictive disorders and in suicidal behavior. These studies focus on early information processing and the balance between initiation and inhibition of action. We have shown that early, pre-attentive responses to stimuli are related to impulsive behavior and impaired response inhibition, with potential consequences including medically severe suicidal attempts. Catecholamine system function, interacting with glutamatergic and peptidergic systems, has a strong role in these phenomena. I also participated in a case control study of medically severe suicide attempts, funded by the Centers for Disease Control and National Institute on Alcohol Abuse and Alcoholism, where we studied potentially lethal impulsive and non-impulsive suicide attempts. I have carried out substantial research with lithium, including its effects on catecholamine systems in bipolar disorder and in animal models, its effects on behavior, and its pharmacology. Human behavioral research has also focused on mechanisms by which depression combines with pathological activation, an important mechanism in suicide risk. My work in animals has focused on mechanisms of behavioral sensitization that appear to link catecholamine function to development of exaggerated behavioral responses to endogenous or exogenous rewards or stressors.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Alcohol and Addiction Research  Appointments Title Department / School Institution Professor Psychiatry & Behavioral Sciences Baylor College of Medicine

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