Horner, Philip (Faculty Profile)

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Faculty Profile

Last Modified Time: 10:22:56 AM Tue, 31 Mar 2020

Contact Information
Philip Horner	Associated Profiles
Professor, Neuroregeneration, Houston Methodist Research Institute


pjhorner@houstonmethodist.org Web Link Horner Lab

Research and Expertise
Affiliations
Appointments

Research and Expertise

Research Interests

The Horner lab is focused on the interaction between glial and neural cells following central nervous system challenge and specifically: 1) mechanisms of adult stem cell-derived lesion remodeling/repair and 2) role of gliogenesis and gliosis in neural degeneration. Over the past decades, researchers have observed that the human brain and spinal cord retain a population of stem cells with the capacity to replace neurons and glia. However, during normal aging and following trauma or disease, the brain and spinal cord stem cells fail to replace needed circuitry. The Horner lab has been developing approaches to modify and amplify the fate of neural stem cells to increase cellular repair after spinal cord and brain injury. Together with electrical stimulation, the lab has shown that regeneration of neural circuitry offers hope for repair nervous system. Together with clinical research partners at Houston Methodist and our global partners, the Horner lab seeks to move from bench to bedside by engineering new neural circuits in people with chronic paralysis in order to restore hand function. Neural regeneration strategies are also being applied to stroke, head injury, glaucoma and motor/cognitive decline associated with aging.

Publications/Creative Works

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Affiliations

Research Consortia

Gulf Coast Cluster for Regenerative Medicine

Appointments

Title	Department / School	Institution
Professor	Neuroregeneration	The Methodist Hospital Research Institute

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