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Faculty Profile Last Modified Time: 10:20:56 AM Tue, 31 Mar 2020   Contact Information Nancy Huang Associated Profiles  Associate Professor, Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology -TAMHSC     2121 W. Holcombe Blvd., Houston, TX 77030     Center for Epigenetics & Disease Prevention    yun.huang@tamu.edu     713-677-7484    Web Link    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Imbalanced DNA methylation/demethylation results in abnormal gene expression and increased genome instability, which is frequently observed in human cancers. Dr. Huang 's research interests are directed towards understanding how DNA methylation/demethylation balance is maintained in mammals and how aberrant DNA methylation and its oxidation products contribute to human cancer. Dr. Huang's ongoing research includes using high-throughput sequencing to study the DNA modifications in human cancer, elucidating the role of DNA modification enzymes in mouse models, and exploring novel anti-cancer or preventive strategies by targeting key epigenetic pathways. Dr. Huang has significantly contributed to the functional characterization of the ten eleven translocation (TET) enzymes in hematological malignancies. Dr. Huang also pioneered the use of innovative tools to probe the "sixth DNA base", 5-hydroxymethylcytosine (5hmC), in the human genome and was among the first to profile the hydroxylmethylome in mouse embryonic stem cells.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster for Cellular and Molecular Biophysics Gulf Coast Cluster for Single Cell Omics  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Associate Professor Center for Epigenetics & Disease Prevention Institute of Biosciences and Technology -TAMHSC

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