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Faculty Profile Last Modified Time: 12:13:45 PM Mon, 30 Mar 2020   Contact Information Robert Dantzer Associated Profiles  Professor, Internal Medicine, UT MD Anderson Cancer Center, Adjunct Professor, Psychiatry and Behavioral Sciences, UT Health Science Center Houston     rdantzer@mdanderson.org    Web Link    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Behavioral Neuroscience University Paul Sabatier 1977  Research and Expertise Research Interests   My research focuses on the neuroimmune basis of depression and fatigue in the context of inflammation and cancer and its therapy. After having shown that inflammation propagates from the site of the body in which it is initiated to the brain via several immune-to-brain communication pathways and induces behavioral signs of sickness and depression we aim now at determining whether these communication pathways can be targeted at the level of the blood-brain barrier. We also study the mechanisms responsible for the development of signs of sickness and fatigue in animal models of cancer and cancer therapy. This research is carried out on a murine model of human-papilloma virus-related head and neck cancer. We study in particular the role of inflammation in the behavioral alterations associated with tumor growth and the involvement of mitochondrial dysfunction in the behavioral alterations associated with a curative regimen of cisplatin and radiotherapy. To elucidate the neuroimmune basis of fatigue, we focus on the motivational component of this symptom by parallel studies carried out in mouse models and in cancer patients. The ultimate goal of our research is the identification of druggable targets for the prevention and treatment of fatigue and depression.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Mental Health Research Cluster  Appointments Title Department / School Institution Adjunct Professor Psychiatry and Behavioral Sciences UT Health Science Center Houston Professor Internal Medicine UT MD Anderson Cancer Center

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