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Faculty Profile Last Modified Time: 12:10:24 PM Mon, 30 Mar 2020   Contact Information Jiaqian Wu Associated Profiles  Associate Professor, Neurosurgery, UT Health Science Center at Houston   SRB 637C    jiaqian.wu@uth.tmc.edu     713.500.3421    Web Link    GSBS Faculty Page    Genes Transcriptome Human Genome RNA Sequence Analysis Genome Complementary DNA Spinal Cord Injuries Long Noncoding RNA RNA Polymerase Chain Reaction Exons Reverse Transcription Oligodendroglia Arabidopsis Clone Cel    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Wu laboratory combines stem cell biology and systems-based approaches involving genomics, bioinformatics and functional assays to unravel gene transcription and regulatory mechanisms governing stem cell differentiation. One major focus of our group is investigating stem cell neural differentiation and developing effective and safe treatment for spinal cord injury and neurological diseases. We are studying gene expression and the regulation of transcription factors and regulatory RNAs using next-generation sequencing technologies including RNA-Seq, ChIP-Seq, and ATAC-Seq etc. These studies are crucial in understanding the molecular mechanism of stem cell neural differentiation and its clinical implications. Our goal is to identify and modulate key regulators as therapeutic targets to direct the differentiation of stem cell into desired neural cell types more efficiently, and to increase transplantation safety. The other area of our research interest lies in the studies of the regulatory networks of hematopoietic precursor cell self-renewal and differentiation using multipotent EML (erythroid, myeloid, and lymphocytic) cell as a model system. We are using integrated genomic and proteomic approaches to identify key components that control the switch. We have identified TCF7, together with RUNX1 are important regulators in this process. Future study will generate a global interaction network and a novel and comprehensive view of the regulation of early stages of hematopoietic precursor self-renewal and differentiation. This study can serve as a model for the analysis of cell self-renewal and differentiation in general and provide insight for efficient expanding and manipulating hematopoietic precursor and stem cells.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Regenerative Medicine Gulf Coast Cluster for NeuroEngineering GCC Cluster for Alcohol and Addiction Research Gulf Coast Consortium for Translational Pain Research Gulf Coast Cluster for Single Cell Omics  Appointments Title Department / School Institution Associate Professor Neurosurgery UT Health Science Center at Houston

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