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Faculty Profile Last Modified Time: 10:39:19 AM Tue, 31 Mar 2020   Contact Information Yong Li Associated Profiles  Associate Professor, Pediatric Surgery, UT Health Science Center at Houston     Yong.Li.1@uth.tmc.edu     713-500-2438    Web Link    Adult Stem Cell Regulation, Musculoskeletal Regeneration, Fibrosis, Translational Studies    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Gene Therapy, Cellular Biology and Pathology Third Military Medical University 1996  MD Medicine Shanghai Second Medical University 1993  Research and Expertise Research Interests   Our team has developed several novel techniques for molecular, cellular and small animalbased research to focus on two major areas of study: 1) exploring the properties of the dedifferentiation/transformation of terminally differentiated cells into various stem cells for regenerative medicine and tissue engineering applications; 2) studying the processes involved with fibrous scar formation and prevention in the injured and diseased tissues of the neuron and musculoskeletal system; and 3.) Bioengineering to build 3D softy tissues (muscle & tendon) to repair wound defect with scarless healing. The laboratory is also interested in translational study and clinical application of stem cells and engineered tissue for treating congenital diseases and traumatic injuries. We have also set up classic amphibian models of tissue regeneration; newts and salamanders can rebuild most missing body parts such as limbs, liver, lens and heart after amputation injury. However, injured mammalian tissue, including that of humans, is usually replaced with fibrotic scar tissue at the end of the healing process. Our aim is to determine the mechanism(s) behind the regenerative process in amphibians and ascertain the relationship(s) to human tissue or organ regeneration. We will investigate the cellular dedifferentiation process for increasing the stem cell population and methods of preventing fibrotic scar tissue formation during wound healing. Our expectation is to transfer our learning from amphibian regenerative models to enlarge stem cell pool for regenerative medicine applications, and to build various functional human tissues/organs for human patients' demand.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Associate Professor Pediatric Surgery UT Health Science Center at Houston

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