Engineering Synthetic Regulatory Circuitry, Mammalian Gene and Signal Transduction Circuits, Harnessing Mammalian Synthetic Biology to Create Cell-Based Therapeutics, How Biological Behavior Arises from Network Structure
Caleb Bashor uses approaches in synthetic biology to understand how complex behavior emerges from the properties of components that comprise cellular regulatory networks. His research focus is on engineering synthetic regulatory programs capable of reshaping cellular phenotype, with an eye on developing transformational cell-based therapeutics from engineered human cells. The Bashor lab utilizes diverse eukaryotic cell types (mammalian immune and stem cells) to learn how to reprogram the complex regulatory circuitry involved in cellular sense and response. His approach uses theory and modelling to guide circuit design, and incorporates DNA assembly, microfluidics, and next-generation sequencing to build and characterize circuit libraries in high-throughput.
Publications/Creative Works
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