Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 12:08:39 PM Mon, 30 Mar 2020   Contact Information Chinnaswamy Jagannath Associated Profiles  Professor, Pathology and Genomic Medicine, Houston Methodist Research Institute   Web Link    Infection, Infectious Diseases, Tuberculosis, Macrophage, T Lymphocytes, Mycobacterium Tuberculosis, HIV Immunology, Dendritic Cells, Vaccinology, HIV Vaccine, T Cell Signaling, Macrophages Proteomics    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Medical Microbiology University of Madras 1984  Research and Expertise Research Interests   My laboratory investigates the immunological mechanisms of vaccines and adjuvants, focusing on tuberculosis, which is the leading cause of death due to infections in mankind. The BCG vaccine and Mycobacterium tuberculosis organisms are processed by the antigen presenting cells like macrophages and dendritic cells (APCs), and peptides presented to CD4 and CD8 T cells through MHC-II and MHC-I pathways to trigger Th1 immunity. However, both the vaccine and pathogen sequester within APCs and evade immune evasion. The major emphasis of our laboratory is therefore to increase the antigen processing mechanisms, improving the efficacy of BCG vaccine and related adjuvants. We have genetically modified BCG vaccine to render it an autophagic vaccine (Nature Medicine 2009) and currently analyzing intracellular TLR and NLR signaling mechanisms to activate APCs. A tutorial in my laboratory will therefore give an insight into the intracellular mechanism of APCs, especially autophagy-dependent antigen processing mechanisms and help to understand the molecular basis for host-defense. Another thrust area is the induction of long term memory to infections through enhancing APC-T cell cross talk. We pioneered the use of rapamycin to induce autophagy to boost vaccine efficacy and also increase immune memory mediated by CD4 and CD8 T cells. We are using mouse models to investigate the immunological basis of vaccine and adjuvant driven long-term immunity mediated by CD8 and CD4 T cells against tuberculosis. Since BCG can be engineered to deliver heterologous antigens, we are also developing a global vaccine platform using the live attenuated BCG vaccine. A rotation in my laboratory will therefore provide cutting-edge solutions to improve vaccines and adjuvants and strengthening host immunity.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Scientist   Houston Methodist Research Institute

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.