Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 11:49:46 AM Mon, 30 Mar 2020   Contact Information Robert Hunter Associated Profiles  Distinguished Professor and Chair, Pathology and Laboratory Medicine, UT Health Science Center at Houston   MSB 2.126    Robert.L.Hunter@uth.tmc.edu     713.500.5301    Web Link    Clinical Pathology, Immunology, Autopsy Pathology, Immunopathology, Pathogenesis of Tuberculosis    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   University of Chicago 1969  MD   University of Chicago 1965  Research and Expertise Research Interests   Development of vaccines and host directed therapies for post-primary tuberculosis (TB) is impeded by a flawed paradigm that granulomas are the key lesion of both primary and post-primary TB. As a result, investigators have neither reliable targets nor biomarkers. This paradigm derives from animal studies in the late 20th century. We have rediscovered, confirmed and extended the paradigm that obstructive lobular pneumonia, not granulomas, is the precursor lesion of post-primary TB (1-7). This lesion is seldom seen because it is asymptomatic. It develops in people with sufficient immunity to heal all granulomas. Alveolar macrophages in the least active part of the lung become infected and small bronchioles become obstructed. The lesions spread for months via bronchi before rapidly undergoing necrosis to produce clinical disease. Our recognition of the precursor lesion of post-primary TB and development of an animal model provide both a target and biomarkers for development of host directed therapy. Such therapies involving immune checkpoints are being intensively studied for cancer. We use methods and results of studies with cancer in coordinated studies of human and mouse TB to define the microenvironment of developing post primary TB and evaluate agents for host directed therapy of TB.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Distinguished Professor and Chair Pathology and Laboratory Medicine UT Health Science Center at Houston

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.