Research in Dr. Geng's laboratory is aimed at delineating the molecular and cellular mechanisms underlying the pathogenesis of atherosclerosis and heart failure, and at developing new therapeutic approaches to treat cardiovascular diseases with means of molecular and cellular biology. A strong interest is to determine molecular regulation of proliferation, differentiation and death of cardiovascular cells under both physiological and physiological conditions. Current studies focus on identifying new genes that regulate apoptosis and caspase activities, analyzing new lipid-binding proteins in atherosclerosis, and developing transgenic and knockout murine models for atherosclerosis and heart failure. The lab also uses molecular biology and tissue engineering techniques to transplant fetal cardiac myoblasts and deliver new genes to the heart with ischemic injury.
Publications/Creative Works
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