Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 11:36:45 AM Mon, 30 Mar 2020   Contact Information Brian Davis Associated Profiles  C. Harold and Lorine G. Wallace Distinguished University Chair, Director, Center for Stem Cell & Regenerative Medicine, Institute of Molecular Medicine, UT Health Science Center at Houston   IMM/SRB 630E    Brian.R.Davis@uth.tmc.edu     713.500.3145    Web Link    Gene Editing, iPSCS, Lung Diseases, Stem Cells, DNA Repair, Novel Gene Therapeutics, Gene Mutations, Inherited Genetic Diseases    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Physics California Institute of Technology 1980  BA Physics Harvard University 1976  Research and Expertise Research Interests   The research in my laboratory is focused on gene editing in stem cells, that is utilizing homologous recombination and/or DNA repair processes to restore an endogenous mutant gene sequence to the corrected normal sequence in autologous stem cells obtained from patients with inherited genetic disease. Alternately, gene editing could be used to introduce specific changes (e.g. SNPs) into genes in normal stem cells for a functional evaluation of such changes. One line of investigation has been to develop novel gene therapeutics using Zinc Finger Nuclease (ZFN) facilitated gene editing to correct gene mutations or target integration of transgenes into specific chromosomal sites directly in hematopoietic stem/ progenitor or mesenchymal stem cells. Such corrected stem cells would be transplanted back into patients with inherited genetic diseases such as primary immunodeficiencies (e.g. X-linked SCID, Wiskott-Aldrich Syndrome) or muscular dystrophies. We hypothesize that direct correction of mutations or targeted transgene integration at the endogenous chromosomal location, under native gene transcriptional control, should result in more physiologic correction of defects than that achievable through random gene addition approaches. A second line of investigation is focused on spontaneous somatic reversion of inherited mutations or "natural gene therapy" in patients with inherited genetic disease. This project has developed out of our identification of numerous genetic revertants in a patient with Wiskott-Aldrich Syndrome. This provides an unprecedented snapshot of natural selection at work within a patient with an inherited genetic disease – acting upon a repertoire of mutant genotypes to select those encoding protein(s) with greatest functionality.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution C. Harold and Lorine G. Wallace Distinguished University Chair Institute of Molecular Medicine UT Health Science Center at Houston

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.