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Faculty Profile Last Modified Time: 11:32:04 AM Mon, 30 Mar 2020   Contact Information Diane Bick Associated Profiles  Professor, Pathology and Laboratory Medicine, UT Health Science Center at Houston   MSB 2.232A    Diane.L.Bick@uth.tmc.edu     (713)500-5328    Mitochondrial Lipid Metabolism, Autophagy, Cell Death    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular Physiology & Biophysics Baylor College of Medicine 1993  BSc Medical Biochemistry University of Birmingham 1975  Research and Expertise Research Interests   The goal of the research in my laboratory is aimed at understanding the control of cardiac metabolism in health and disease. Cardiomyocytes are terminally differentiated cells and cell death leads to a functional loss of these cells. My laboratory is interested in the loss of cardiomyocytes by programmed cell death, or apoptosis, particularly with respect to the events initiated within the mitochondrion. Mitochondrial changes, including the release of cytochrome c and the loss of the mitochondrial specific lipid, cardiolipin, have been implicated as early events in apoptosis initiated by diverse stimuli. Of particular interest in my laboratory is the role that cardiolipin synthesis and metabolism has on the susceptibility of the cardiomyocyte to apoptosis. My laboratory is also interested in the role bacterial lipopolysaccharide (LPS) on cardiac function and metabolism. LPS, a component of bacterial cell walls, induces multiple organ responses and can lead to ultimately to toxic shock and death. One of the clinically important sequellae of LPS exposure is damage to the heart. The role of apoptosis in this cardiac damage is not clear and we seek to integrate our understanding of the induction of apoptosis with the immune response that LPS stimulates.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Professor Pathology and Laboratory Medicine UT Health Science Center at Houston

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