Nature provides a vast collection of biological systems which have evolved mechanisms to achieve catalysis, regulation, molecular recognition, and energy utilization with incredible efficiency. Our ability to successfully re-design and harness such systems is integral to realizing a future of cost-effective "green" chemistry, renewable fuels and chemicals, bioremediation, and "next-generation" therapeutics. Research in the Cirino laboratory interfaces Chemical Engineering with the biological sciences, with emphases in biomolecular engineering, metabolic engineering, and biocatalysis. Recent research efforts are summarized in the poster presentations below (right click to view larger images). By applying biological design principles at the molecular level (e.g., engineer proteins) as well as the systems level (e.g., engineer metabolic pathways and gene regulation) we are creating novel microbial strains with improved biocatalytic efficiency (e.g. increased supply of NADPH to transformations of interest), and we are designing novel biosensors by customizing regulatory proteins, with broad applications in synthetic biology and biocatalyst development.
Publications/Creative Works
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