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Faculty Profile Last Modified Time: 08:40:22 AM Sat, 7 Jul 2018   Contact Information Cullen M. Taniguchi Associated Profiles  Assistant Professor, Radiation Oncology, UT MD Anderson Cancer Center   MDA Z3.3030, Room No.: Unit 97    CTaniguchi@mdanderson.org    Web Link    Lab Webpage    Hypoxia Biology, Tumor Microenvironment, Pancreatic Cancer, Radioprotective Agents, Radiation Biology of SBRT    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD Medicine Harvard Medical School 2008  PhD Cell and Developmental Biology Harvard Medical School 2005  M Phil Economic and Social History University of Oxford 2000  BA Chemistry Occidental College 1998  Research and Expertise Research Interests   The Taniguchi Lab seeks to improve the therapeutic ratio of cancer treatments by understanding and exploiting the biology of hypoxia, or low oxygen, to improve outcomes for pancreatic and hepatobiliary cancers. The prolyl hydroxylase domain-containing (PHD) proteins use molecular oxygen to regulate a wide array of pathways, and are thus the body's oxygen sensors. These oxygen sensors can exert powerful cell survival effects, chiefly through the regulation of the hypoxia inducible factor (HIF) family of transcription factors. Our interest in the PHD/HIF pathway is twofold: 1) What is the role these oxygen sensing proteins play within the tumor microenvironment to affect tumor growth and response to chemoradiation treatments? 2) Can we exploit the healing properties enabled by the PHD/HIF pathway to protect normal tissues from chemotherapy and radiation toxicity. To study the role of these PHD proteins in the tumor microenvironment, we independently devised a novel dual recombinase system where stromal components are regulated with Cre/lox and tumor components are regulated independently. This model improves on xenografts, which do not have a significant stroma or immune response. We have also studied the role of PHD proteins in protecting the GI tract from radiation damage and wish to extend these studies to other tissues so that every normal tissue in the body can be selectively protecting from chemotherapy and radiation damage without compromising tumor kill. Our studies in cell culture and complex animal models are designed to be immediately relevant to human disease and to leverage Dr. Taniguchi's role as a Radiation Oncologist at MD Anderson to translate these findings to clinical trials.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Assistant Professor Radiation Oncology MD Anderson Cancer Center

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