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Faculty Profile Last Modified Time: 07:10:10 AM Fri, 20 Jul 2018   Contact Information Amy B. Heimberger Associated Profiles  Professor, Neurosurgery, UT MD Anderson Cancer Center   1400 Holcombe Blvd, Room No.: Unit 442    aheimber@mdanderson.org     713-563-8717    Web Link    Lab Webpage    Glioma, Glioblastoma, Neoplasms, Immunotherapy, STAT3 Transcription Factor, Temozolomide, Epidermal Growth Factor Receptor, Brain Neoplasms, Therapeutics, T-Lymphocytes, Regulatory T-Lymphocytes, Survival, Immunosuppression    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD Medicine Washington University 1995  BA Biology University of Missouri 1989  Research and Expertise Research Interests   Dr. Amy Heimberger is a Professor in the Department of Neurosurgery at MD Anderson Cancer Center in Houston and has been a member of the department since 2002. She has an extensive research program focused on immune therapeutic strategies for glioma patients and studies tumor-mediated mechanisms of immune suppression. Her laboratory, the Brain Tumor Immunology Lab , was pivotal in the development of a peptide (PEP-3-KLH/CDX-110) vaccine strategy that targets the epidermal growth factor receptor. The strategy doubled the median survival of glioblastoma multiforme patients and is proceeding to final registration clinical trials (licensed to Celldex Therapeutics). In addition, Dr. Heimberger has clarified that the signal transducer and activator of the transcription 3 (STAT3) pathway is a key molecular hub of gliomagenesis and tumor-mediated immune suppression. She also conducted the pre-clinical development of a novel small molecule inhibitor of STAT3, WP1066, which will be introduced into clinical trials in the next 18 months for melanoma patients with CNS metastasis and primary glioma patients. Furthermore, she showed that tumor-associated microglia/macrophages potentiate gliomagenesis via STAT3 and established that the glioma-associated cancer stem cells via the STAT3 pathway exert immune suppressive properties on both the adaptive and innate arms of the immune system.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Professor Neurosurgery MD Anderson Cancer Center

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