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Faculty Profile Last Modified Time: 08:18:16 AM Thu, 19 Jul 2018   Contact Information Khandan Keyomarsi Associated Profiles  Hubert L. and Olive Stringer Professorship, Medical Oncology, Professor, Experimental Radiation Oncology, Professor with Commendation, Graduate School in Biomedical Sciences, UT MD Anderson Cancer Center   MDA Z6.3012, Room No.: Unit 0066    kkeyomar@mdanderson.org     713.792.4845    Web Link    Cyclin E, Breast Neoplasms, Molecular Weight, Neoplasms, Cell Cycle, Cyclins, Breast, Elafin, Protein Isoforms, Lovastatin, Cyclin-Dependent Kinases, Epithelial Cells, Down-Regulation, Tumor Cell Line, Cell Line    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biochemistry University of Southern California 1989  BA Pharmacology University of California at Santa Barbara 1983  Research and Expertise Research Interests   The research in my laboratory is focused on the development of novel strategies for treatment and prognosis of breast cancer by combining experimental therapeutics with cell biology while targeting the cell cycle. To this end, the laboratory is currently involved in 5 areas of research, which fall into translational and basic research categories: *Investigation of the low-molecular-weight (LMW-E) forms of cyclin E as prognostic markers in breast cancer for routine use in the clinic. *Inhibition of LMW forms of cyclin E as a therapeutic target in combination therapy for triple negative breast cancer. *Delineation of how the alteration of cyclin E, a G1 cyclin, could lead to the tumorigenic phenotype and determination of the oncogenic potential of the altered forms of cyclin E in breast cancer. *Determination of the mechanism of action of intracellular elastase and its inhibitor elafin in tumorigenesis and subsequent metastasis. *Examination of mechanisms of action and resistance to CDK4/6 inhibitors in ER +breast cancer patients.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Professor Experimental Radiation Oncology MD Anderson Cancer Center

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