Our laboratory program involves the use of molecular imaging techniques to investigate biological problems, and typically have as a goal the translation of a technique or method to eventual clinical practice. The majority of our work is in diseases of the nervous system, ranging from Chemotherapy Induced Neuropathy, to new imaging methodologies for brain tumors. Examples of projects would include: determining the efficacy of a novel therapy targeted at glycolysis in brain tumors by means of hyperpolarized MR imaging, or determining the effects of graduated radiation doses on the spinal cord, and measuring those effects by means of a retrograde axonal transport imaging readout. Our clinical program involves the performance of research in patients, focused on improving the imaging care provided to patients or developing new imaging methodologies to fulfill unmet needs. We have active programs in the use of imaging to improve the targeting of stereotactic biopsies in brain tumors, and the use of Dual Energy CT and Phase Sensitive MR to characterize brain lesions. Examples of projects would include assisting with the running of trials, helping to analyze imaging data, select biopsy sites, care of specimens and correlative analyses between imaging and biopsy samples.
Publications/Creative Works
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