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Faculty Profile Last Modified Time: 08:09:57 AM Thu, 19 Jul 2018   Contact Information David J. Piwnica-Worms Associated Profiles  Director Ad Interim, Center for Advanced Biomedical Imaging, Gerald Dewey Dodd, Jr. Endowed Distinguished Chair, Diagnostic Imaging, Professor, Cancer Systems Imaging, UT MD Anderson Cancer Center   MDA 3SCR4.3640, Room No.: Unit 1907    dpiwnica-worms@mdanderson.org     713.745.0850    Web Link    Lab Webpage    Neoplasms, P-Glycoprotein, Technetium, Multiple Drug Resistance, Molecular Imaging, Imaging Techniques, Technetium Tc 99m Sestamibi, Luciferases    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD Medicine Duke University 1984  PhD Cell Physiology Duke University 1984  BS Mechanical Engineering Stanford University 1978  Research and Expertise Research Interests   Genomic lesions within incipient cancer cells in collaboration with alterations in the microenvironment contribute to neoplastic progression. Tumor cells can modulate the surrounding microenvironment to promote the progression of cancer through intrinsic oncogenic pathways. However, the importance of the host microenvironment in neoplastic progression, independent of tumor manipulation, is also underscored by studies demonstrating that many stromal and immune cell types stimulate growth of pre-neoplastic and neoplastic cells along with promoting drug resistance. Given these observations, understanding the complex interactions between genomic lesions and tumor microenvironment in animal models is crucial to understanding mechanisms of transformation and uncovering new anti-cancer therapies. Thus, non-invasive imaging technologies have become increasingly important for providing spatial and temporal resolution of biological structure and function, particularly for defining the context of gene expression and protein function, and their regulatory mechanisms within the proper physiologic context of cellular micro-environments. Molecular imaging is used to interrogate protein processing, protein-protein interactions, gene expression and flux through metabolic pathways in real-time in cells, live animals, and humans, and is an increasingly useful tool for understanding signal transduction, pharmacodynamics, and the pathobiology of human diseases in vivo, facilitating development of effective therapies. Techniques: Molecular imaging is broadly defined as the characterization and measurement of biological processes in living animals, model systems and humans at the molecular and cellular level using remote imaging detectors such as PET, SPECT, hyperpolarized MR, bioluminescence, and near-infrared fluorescence. We actively incorporate single cell imaging strategies, high throughput screens of cell phenotypes, cell and molecular biology techniques and conjugation chemistry into our projects.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX Gulf Coast Cluster for Translational Imaging  Appointments Title Department / School Institution Professor Cancer Systems Imaging MD Anderson Cancer Center Interim Director Center for Advanced Biomedical Imaging MD Anderson Cancer Center Gerald Dewey Dodd, Jr. Endowed Distinguished Chair Diagnostic Imaging MD Anderson Cancer Center

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