The Contrast Agent Molecular Engineering Laboratory (CAMEL) develops molecular imaging methods that evaluate biomarkers of the tumor microenvironment, including extracellular acidosis, hypoxia, enzyme activity and redox state. We specialize in the synthesis and characterization of chemical contrast agents for magnetic resonance imaging (MRI), positron emission tomography (PET), PET/MRI, and MultiSpectral Optoacoustic Tomography. We develop advanced acquisition and analysis methods that are tailored for each contrast agent and tumor biomarker. We apply our imaging methods to evaluate the early response to treatment in tumor models, and to improve molecular imaging assessments of patients who have cancer or who are undergoing cancer treatment. CAMEL is a highly multidisciplinary research environment that encourages collaborations with colleagues from many backgrounds, and invites students from a variety of educational programs to joining our research training environment. Our research program focuses on the development of molecular imaging methods that evaluate the tumor microenvironment, which are used to improve cancer diagnoses and personalized treatment. We aim to develop and apply molecular imaging methods that can predict the outcome of cancer treatment before the treatment is initiated, and can evaluate the early response to treatment that can foreshadow the long-term outcome of the treatment. These outcomes can be used to personalize the treatment regimen, by selecting a more appropriate treatment, or by adjusting the dose amount or dose schedule.
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