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Faculty Profile Last Modified Time: 09:16:32 AM Sat, 7 Jul 2018   Contact Information Seth T. Gammon Associated Profiles  Assistant Professor, Cancer Systems Imaging, UT MD Anderson Cancer Center     STGammon@mdanderson.org    Web Link    Optical Imaging, Imaging Techniques, Molecular Imaging, Peptides, Bacterial Infections, Molecular Probes, Bioluminescence, Caspases    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Chemical Biology Washington University 2007  BS Biophysics University of Illinois, Urbana-Champaign 2000  Research and Expertise Research Interests   Imaging, both aesthetic and scientific, drives our imagination and passion and, when carefully and rigorously applied, delivers data densely packed with quantitative and qualitative information. From super-resolution microscopy to "next-generation" sequencing and PET/MRI, imaging techniques and technologies form the foundation of cutting-edge clinical and preclinical research. Dr. Gammon's goal is to contribute to this long tradition by expanding the scientific power of imaging and extracting more information using existing techniques in preclinical research and, eventually, clinical practice. Prior to his arrival at MD Anderson, Dr. Gammon worked on problems in fluorescence correlation spectroscopy, bioluminescence spectral unmixing, bioluminescence resonance energy transfer, and bioluminescence reporters for myeloperoxidase activity in vivo. That work resulted in the development of software for simultaneously studying multiple pathways in live cells (Gammon ST et al. Anal Chem 2006) and the ability to predict optimal luciferase/fluorophore BRET from published spectra (Gammon ST and Villalobos VM et al. Biotechnol Prog 2009). Furthermore, with inexpensive commercially available reagents such as luminol sodium salt, one can monitor myeloperoxidase activity in vivo to study the activation of specific branches of the innate immune system, particularly neutrophils and macrophages (Gross S and Gammon ST et al. Nat Med 2009). Here, his research focuses on novel imaging strategies that are based on rigorous mechanistic studies for noninvasive monitoring of bacteria, activation of the innate immune system, and their interaction with tumors in preclinical models. This includes: 1) Developing new hyperpolarized MRI agents for study of the adaptive and innate immune systems. 2) Leveraging existing bioluminescent and fluorescent reporters for studying the complex interaction of the innate immune system, tumor biology, and cancer chemotherapeutics. 3) Using quantitative PET/SPECT/CT techniques for imaging of the pharmacodynamics of novel therapies in preclinical animal models. 4) Developing novel methods of extracting new information from existing imaging techniques and contrast agents in the context of tumor progression and intervention in preclinical models.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Assistant Professor Cancer Systems Imaging MD Anderson Cancer Center

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