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Faculty Profile Last Modified Time: 12:09:51 PM Wed, 18 Jul 2018   Contact Information Peter Melby Associated Profiles  Professor, Director, Infectious Disease, UT Medical Branch at Galveston, Director, UTMB Center for Tropical Diseases     pcmelby@utmb.edu     (409) 772-0644    Web Link    Leishmania Donovani, Visceral Leishmaniasis, Parasites, Cutaneous Leishmaniasis, Infection, Cytokines, Leishmaniasis, Leishmania    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD Medicine University of Colorado 1983  Research and Expertise Research Interests   Our research is focused on understanding the determinants of immunity and molecular mechanisms related to the immunopathogenesis in leishmaniasis. We have characterized a program of Leishmania-induced alternative macrophage activation in progressive visceral leishmaniasis, defining the regulation of inducible nitric oxide synthase and arginase in macrophages and fibroblasts, and identifying the key role of STAT6 signaling. We have also investigated the impact of malnutrition on innate immunity and visceral leishmaniasis, and ongoing work is focused on characterizing the mechanisms of impairment of lymph node function during polynutrient deficiency. We have used several approaches to identify vaccine candidates for leishmaniasis, and have defined vaccine efficacy in experimental infection models. We are particularly interested in the use of vaccination to interrupt transmission from the reservoir host (dogs) to the insect vector (sand flies) in regions endemic for visceral leishmaniasis.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Consortium for Antimicrobial Resistance (GCC AMR) Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor Infectious Diseases UT Medical Branch at Galveston

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