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Faculty Profile Last Modified Time: 10:56:48 AM Wed, 18 Jul 2018   Contact Information Richard B Pyles Associated Profiles  Professor, Pediatrics, UT Medical Branch at Galveston   Room No.: 3.206E    rbpyles@utmb.edu     Ext. 78142    Influuent Profile    Web Link    Human Herpesvirus 2, Virus Diseases, Herpes Genitalis, Respiratory Tract Infections, Mycoplasma Genitalium, Otitis Media, Guinea Pigs, Epithelial Cells, Viruses, Human Herpesvirus 1, Simplexvirus, Hepacivirus, Infection, Francisella Tularensis    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   My research interests have focused on the interaction of herpes simplex virus types 1 and 2 (HSV-1 and 2) with the nervous system of the human host. Three areas of research have been developed that collectively study the key viral and host factors involved in the acute, latent and reactivated stages of the HSV life cycle. A primary area of research examines immune modulation as an enhancement for vaccine efficacy and antiviral therapies. In these studies we are investigating immunostimulatory, CpG motif-containing oligonucleotides. A second area of research examines neuronal and host genetic factors that contribute to HSV pathology. Our third research area utilizes recombinant viruses that carry alterations in key viral proteins to study the contribution of viral factors to pathogenesis including reporter viruses, expressing fluorescent proteins, with intact genetic compliments to better understand lytic and latent phases of the viral infection.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Consortium for Antimicrobial Resistance (GCC AMR)  Appointments Title Department / School Institution Professor Pediatrics UT Medical Branch at Galveston

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