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Faculty Profile Last Modified Time: 08:27:05 AM Tue, 24 Jul 2018   Contact Information Danielle Garsin Associated Profiles  Professor, Microbiology and Molecular Genetics, UT Health Science Center at Houston   Medical School Building, Room No.: 1.168    Danielle.A.Garsin@uth.tmc.edu     713-500-5454    Web Link    Lab Webpage    Enterococcus Faecalis, Caenorhabditis Elegans, Virulence, Ethanolamine, Biofilms, Transcription Factors, Reactive Oxygen Species, Genes    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biochemistry Harvard University 1999  BS Biological Science Cornell University 1993  Research and Expertise Research Interests   The research in my laboratory is directed at understanding the genetics of bacterial infection from both the pathogen and the host's perspectives. Specifically we have developed C. elegans as a model host for Enterococcus faecalis pathogenesis, to elucidate mechanisms of host defense and bacterial virulence. Projects in my laboratory include (1) characterization of how the worm produces reactive oxygen species (ROS) in response to pathogens, a defense mechanism analogous to the oxidative burst that occurs in human phagocytic cells. We are in the process of identifying the machinery and the regulators that generate this response and characterizing its role in C. elegans immunity. Additionally, a screen for E. faecalis virulence determinants using C. elegans identified ethanolamine utilization as important during infection. A second project (2) is currently investigating how ethanolamine utilization is regulated in E. faecalis. We have discovered several novel mechanisms of post-transcriptional regulation that are actively being studied.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Consortium for Antimicrobial Resistance (GCC AMR)  Training Grants Training Program in Antimicrobial Resistance (TPAMR) Molecular Basis of Infectious Diseases Training Grant Antimicrobial Resistance Training Program in the Texas Medical Center (AMR-TPT)  Appointments Title Department / School Institution Professor Microbiology and Molecular Genetics UT Health Science Center Houston

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