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Faculty Profile Last Modified Time: 12:00:15 PM Fri, 27 Mar 2020   Contact Information Alexander Bukreyev Associated Profiles  Professor, Pathology and Microbiology & Immunology, UT Medical Branch at Galveston     alexander.bukreyev@utmb.edu     (409) 772-2829    Web Link    Lab Webpage    Ebolavirus, Viruses, Respiratory Syncytial Viruses, Marburgvirus, Vaccines, Human Parainfulenza Virus 3, Viruses, Human Respiratory Syncytial Virus    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular Biology State Research Center of Virology and Biotechnology "Vector" 1993  MS Pharmacy Pyatigorsk Pharmaceutical Institute 1984  Research and Expertise Research Interests   Our lab focuses on investigation of the mechanisms of the high pathogenicity of filoviruses Ebola and Marburg and development of vaccines, antibody treatments and small molecule treatments against these viruses. Our research includes the following specific topics: 1. Investigation of mechanisms of "immune paralysis" caused by filoviruses. 2. Characterization of antibody responses to filovirus infections in humans. 3. Development of therapeutic human monoclonal antibody treatments for filoviruses. 4. Development of mucosal respiratory tract vaccines against filoviruses based on human and non-human paramyxovirus vectors. 5. Development of therapeutics targeting filoviral replication and interferon-antagonist functions. 6. Comparative immunology of bats as a reservoir of filoviruses. 7. Experimental evolution of filoviruses in bats. To get insight into these scientific topics, we are using molecular tools, including reverse genetics (i.e. development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), immunological tools such as multi-parameter flow cytometry, and human immune cells and animal models.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor Pathology UT Medical Branch at Galveston

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