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Faculty Profile Last Modified Time: 08:33:50 AM Mon, 23 Jul 2018   Contact Information Roopa Thapar Associated Profiles  Assistant Professor, Molecular and Cellular Oncology, UT MD Anderson Cancer Center   MDA S7.8136B (Unit 108)    rthapar@mdanderson.org     713.834.6276    Web Link    Histones, Phosphorylation, RNA-Binding Proteins, Carrier Proteins, Messenger RNA, RNA Stability, Proteins, Peptidylprolyl Isomerase    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biochemistry/Structural Biology University of Washington, School of Medicine 1997  Research and Expertise Research Interests   Research in my laboratory is focused on molecular recognition and assembly of large multi-protein and protein-RNA complexes that play important roles in regulation of RNA-mediated gene expression. We use a multi-disciplinary approach combining structural techniques (NMR, SAXS, X-ray crystallography) with biophysical tools (ITC, CD, DSC, Biacore, fluorescence, and sedimentation equilibrium)as well as biochemical and molecular biological approaches to understand the structures of protein-RNA complexes and the mechanisms by with they are regulated. The specific areas of investigation include characterization of lncRNAs important for NHEJ DNA repair regulation in breast and prostate cancers, lncRNA-DNA repair complexes that regulate double-strand break repair, structure and function of novel family of ERI exoribonucleases, alkylation damage repair of RNA and DNA, and complexes involved in histone mRNA metabolism. We are also interested in developing small molecule RNA therapeutics that could act as chemical probes to study RNA processes in vivo or may be useful in directly targeting tumors.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn, Sr. Gulf Coast Consortium for Magnetic Resonance GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Assistant Professor Molecular and Cellular Oncology MD Anderson Cancer Center

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