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Faculty Profile Last Modified Time: 11:57:27 AM Fri, 27 Mar 2020   Contact Information Curtis Pickering Associated Profiles  Assistant Professor, Head and Neck Surgery, UT MD Anderson Cancer Center   MDA T5.3900, Room No.: Unit 123    crpickering@mdanderson.org     713.794.4512    Web Link    Squamous Cell Carcinoma, Mutation, Neoplasms, Head and Neck Neoplasms, Mouth, Cell Line, Biomarkers, Mouth Neoplasms    Associated Profiles Professional Preparation Research and Expertise Appointments  Professional Preparation  Degree Major Institution Year  PhD Cell Biology University of California 2008  BS Biochemistry and Molecular Biology Michigan State University 2001  Research and Expertise Research Interests   My research program is focused on the translational genomics of head and neck cancer.  This lethal and debilitating disease is still treated primarily with surgery, chemotherapy and/or radiation.  Our goal is to improve the treatment of head and neck cancer by understanding the genomic alterations that drive the disease. Our translational research process starts with patient samples or data from previous patient studies, i.e. TCGA.  We have recently characterized the spectrum of genomic alterations in oral tongue cancer and squamous skin cancer.  These studies identified numerous genes of unknown clinical and functional relevance; including NOTCH1, CASP8, FAT1 and AJUBA.  These top candidate alterations are now being studied functionally in the laboratory.  We are also performing high-throughput functional genomic screens to rapidly detect additional key genes.  Finally, pathway analysis has suggested that many of these genes regulate squamous differentiation, and this hypothesis is being investigated in a 3-dimensional organotypic raft culture system.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Assistant Professor Head and Neck Surgery MD Anderson Cancer Center

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