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Faculty Profile Last Modified Time: 03:04:33 PM Thu, 16 Apr 2020   Contact Information Malgorzata Rowicka-Kudlicka Associated Profiles  Assistant Professor, Biochemistry and Molecular Biology, UT Medical Branch at Galveston   Mail Box: 1071, Research Bldg 6, Room No.: 5.214    merowick@utmb.edu     409-772-2245    Web Link    Fourier Analysis, Fast Fourier Transforms, Double-Stranded DNA Breaks, Gene Expression, Genes, Fast Fourier Transformations, Yeasts, Symmetry    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Our lab studies mechanisms of double-strand break (DSB) formation, a cause of genome instability, by combining our innovative experimental method with computational modeling approaches. Despite many studies on the mechanisms of DNA double-strand breaks (DSB) formation, our knowledge of them is very incomplete. To date, DSB formation has been extensively studied only at specific loci but remains largely unexplored at the genome-wide level. This is owing to the lack of systematic, genome-wide studies to objectively test and compare the proposed mechanisms of DSB formation, as well as the lack of high- resolution genome-wide maps of DSBs obtained by direct DSB labeling to validate them. Working with collaborators, we have recently developed a method to label DSBs in situ followed by deep sequencing (BLESS), and used it to map DSBs in human cells with a resolution 2-3 orders of magnitude better than previously achieved. Our results show that hypothesis-driven analysis of high-resolution genomic regions identified by BLESS can help explore the basis of genomic instability genome-wide. Such analysis should eventually allow use of DSB localization signatures for diagnostic and prognostic purposes.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Computational Cancer Biology Training Program  Appointments Title Department / School Institution Assistant Professor Biochemistry and Molecular Biology UT Medical Branch at Galveston

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