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Faculty Profile Last Modified Time: 10:53:38 AM Mon, 23 Jul 2018   Contact Information Helen Piwnica-Worms Associated Profiles  Professor, Experimental Radiation Oncology; Senator A.M. Aikin Jr. Distinguished Chair; Vice Provost, Science, UT MD Anderson Cancer Center   MDA 2SCR4.3025 (Unit 1052)    hpwinica-worms@mdanderson.org     713.745.4495    Web Link    Lab Webpage    Phosphorylation, Phosphotransferases, Cdc25 Phosphatases, Cell Cycle, 14-3-3 Proteins, Serine, Protein Kinases, Tyrosine    Associated Profiles Professional Preparation Research and Expertise Appointments  Professional Preparation  Degree Major Institution Year  PhD Microbiology and Immunology Duke University 1984  BA Biology St. Olaf College 1979  Research and Expertise Research Interests   The goals of my research program are aimed at understanding the function and regulation of proteins involved in cell cycle and checkpoint control; identifying mutations and epigenetic modifications with functional significance to the development and progression of invasive triple negative breast cancer (TNBC); developing and exploiting models that enable cell cycle regulatory proteins, cancer drivers and therapeutic targets to be functionally studied in vertebrate animals and translating results from basic, omic and preclinical studies into improved clinical interventions for breast cancer patients. Recognizing that a key challenge facing breast cancer researchers today is the lack of good preclinical models for studying human breast cancer, we are working with primary human breast tumors obtained directly from patients with TNBC. These tumors are being propagated in the humanized mammary fat pads of immune compromised mice for our discovery, omic and preclinical studies. Many of these human tumors metastasize out of the mammary gland to lung, bone, liver and brain facilitating our studies aimed at identifying drivers of breast cancer metastasis. In addition, we are identifying, characterizing and targeting tumor cells in treatment naïve TNBC that are resistant to front line chemotherapy.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Professor Experimental Radiation Oncology MD Anderson Cancer Center Senator A.M. Aikin Jr. Distinguished Chair   MD Anderson Cancer Center

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