The NIH & DARPA funded FARSIGHT project is developing multi-dimensional image analysis tools to make quantitative measurements and interpretation of images derived from modern optical microscopes. These systems are now capable of recording dynamic processes in living specimens in their spatial anatomical context and temporal order, yielding information-rich 5-D images (3-D space, time, spectra). Of particular interest to me are complex and dynamic tissue microenvironments that play critical roles in health and disease, e.g., tumors, stem-cell niches, brain tissue surrounding neuroprosthetic devices, retinal tissue, cancer stem-cell niches, glands, and immune system tissues. I am blessed with a network of great collaborators in each of these areas, many of whom are linked in. Multi-dimensional images are challenging to analyze (often exceeding human ability), due to their variability and sheer size. There is a need for automated systems to map the tissue anatomy, quantify structures associations, identify critical events, map event locations and timing to the tissue anatomic context, identify spatial and temporal dependencies, produce meaningful summaries of multivariate measurement data, and compare 4-D/5-D datasets for testing hypotheses, exploration, and systems modeling. Looking beyond the need for automaton, there is a need for "computational sensing" methods capable of exceeding human ability in sensing hidden patterns and trends. These tasks are computationally demanding; so, high-performance computing and high-end visualization are integral to my work.
Publications/Creative Works
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Affiliations
Training Grants
NLM Training Program in Biomedical Informatics & Data Science for Predoctoral and Postdoctoral Fellows
Research Consortia
Gulf Coast Cluster for NeuroEngineering
Gulf Coast Consortium for Translational Pain Research
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