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Faculty Profile Last Modified Time: 12:55:47 PM Wed, 29 Mar 2023   Contact Information John Cooke Associated Profiles      jpcooke@houstonmethodist.org    Web Link    Lab Webpage    Nitric Oxide, Blood Vessels, Peripheral Arterial Disease, Nitric Oxide Synthase, Endothelial Cells, Endothelium, Atherosclerosis, Vascular Diseases, Vasodilation, Cardiology    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  MD, PhD Cardiovascular Medicine, Physiology Mayo Clinic School of Medicine 1987  Research and Expertise Research Interests   Dr. Cooke's translational research program is focused on vascular regeneration. The program is funded by grants from the National Institutes of Health, the American Heart Association, and industry. The focus is on restoration or stimulation of endothelial functions such as vasodilation and angiogenesis, using small molecules or stem cell therapies. In his 25 years of translational endothelial biology, he first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials. His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease. More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Regenerative Medicine  Appointments Title Department / School Institution Cardiovascular Disease Research The Methodist Hospital Research Institute

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