Children's Fund Distinguished Professor, Pediatric Surgery, Director of the Pediatric Trauma Program, Children's Memorial Hermann Hospital, Professor, Center for Stem Cell & Regenerative Medicine, UT Health Science Center at Houston
Pediatric Traumatic Brain Injury, Safety of Autologous Mesenchymal Stem Cell Therapy for Spinal Cord Injury in Children, Safety of Autologous Human Cord Blood as a Treatment for Traumatic Brain Injury in Children
The Pediatric Translational Laboratories and Pediatric Program in Regenerative Medicine is a multi-disciplinary effort that addresses problems that originate with traumatic injury and the consequences of resuscitation and critical care. The Program focuses on progenitor cell based therapy (stem cells) for traumatic brain injury, and related neurological injuries (hypoxic-ischemic encephalopathy, stroke, spinal cord injury), recently completing the first acute, autologous cell therapy treatment Phase I study for traumatic brain injury in children (Neurosurgery, 2011). Three subsequent INDs have been approved for cell-based therapies for neurological injury. The program also develops novel bio-hybrid organs using cell-based and tissue engineering approaches to trauma and injury related problems. These efforts have recently resulted in two IND based cell therapeutic studies, and three patents in the past two years. The program is funded through the National Institutes of Health, Texas Higher Education Coordinating Board/Emerging Technology Funds, Industry Collaboration, and philanthropic contributions. The Program is housed in state-of-the-art laboratory facilities (4500 sf), and includes two cGMP facilities for the production of clinical grade cell and tissue products: Hoffberger Cellular Therapeutics Laboratory and the Griffin Stem Cell.
Publications/Creative Works
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