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Faculty Profile Last Modified Time: 10:29:04 AM Mon, 23 Jul 2018   Contact Information Peter G. Wolynes Associated Profiles  Bullard-Welch Foundation Professor of Chemistry, Professor, Chemistry, Physics & Astronomy, Rice University   BioScience Res Collaborative, Room No.: 1005E    pwolynes@rice.edu     713-348-4101    Web Link    Lab Webpage    Proteins, Protein Structure, Protein-Protein Interaction, Statistical Mechanics, Protein Folding, Protein Stability, Protein Dynamics, Protein Aggregation, Free Energy, Structure Prediction    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Chemical Physics Harvard University 1976  AB Chemistry Indiana University 1971  Research and Expertise Research Interests   The research in my group is broadly concerned with many-body phenomena in biology, chemistry and physics. A major theme is understanding systems where a large diversity of long-lived states is involved, necessitating the use of a statistical characterization of an energy or attractor landscape. The most notable examples are glasses, liquids, biomolecules and biomolecular regulatory networks. In the area of protein folding we are interested both in describing folding kinetics in the laboratory and the development of bioinformatically based schemes for predicting structure from sequence using computer simulation. A key concept is that the energy landscape of a foldable protein looks like a rugged funnel. This idea guides the development of both simple folding kinetics models and structure prediction algorithms. Similar issues of attractor landscapes also arise in higher order biological processes, such as gene recognition and genetic network regulation, which we also study. The energy landscapes of supercooled liquids and glasses also present interesting problems. We have shown how a new approach based on "random first order transitions" explains many quantitative relations found empirically both in liquids and under cryogenic conditions where quantum effects play a role. The same ideas show promise in the study of systems as different as high temperature superconductors, polymer assemblies, and microemulsions. They are also useful for describing the three dimensional structure and dynamics of the interior of living cells.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Computational Cancer Biology Training Program Houston Area Molecular Biophysics Training Program  Appointments Title Department / School Institution Professor Chemistry, MSNE, Physics & Astronomy Rice University

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