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Faculty Profile Last Modified Time: 02:36:58 PM Fri, 27 Mar 2020   Contact Information Junjie Chen Associated Profiles  Professor and Chair, Experimental Radiation Oncology, UT MD Anderson Cancer Center   MDA Z6.3038, Room No.: Unit 0066    jchen8@mdanderson.org     713.792.4863    Web Link    Lab Webpage    DNA Damage, Proteins, DNA, Genomic Instability, DNA Repair, Repair, Neoplasms, Recombinational DNA Repair    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Cell and Molecular Biology University of Vermont 1993  MS Physiology Institute of Plant Physiology, Academia SINICA 1989  BS Genetics/Genetic Engineering Fudan University 1988  Research and Expertise Research Interests   The Junjie Chen Laboratory focuses on understanding molecular mechanisms underlying genomic instability and tumorigenesis. Maintenance of genome integrity following DNA damage requires the coordination of DNA repair with various cell-cycle checkpoints. The hope is that by understanding these DNA damage-responsive pathways, we will know how deregulation of them contributes to tumor initiation and/or progression and how to take advantage of this deregulation in cancer therapy. The laboratory has been studying DNA damage signaling and DNA repair pathways since 1999. We have identified and performed in-depth functional studies of many key cell-cycle checkpoint and DNA repair proteins in several DNA damage signaling and repair pathways. With the increasing appreciation of intricacy of signaling pathways, it becomes evident that we need to go beyond our studies of individual proteins and pathways. We should achieve a comprehensive understanding of the network involved in DNA repair and determine how these proteins and pathways intersect, interact, communicate, coordinate, and collaborate for genome maintenance. Only by elucidating the complexity of DNA repair network will we be able to make meaningful and decisive contributions to cancer biology and treatment. With this in mind, we successfully carried out several genome-wide to medium- and small-scale network studies in various DNA repair and oncogenic signaling pathways. The goal is to combine our ability to conduct network analysis with our expertise in performing detailed mechanistic studies to establish physical and functional networks of DNA damage response, tumor suppressive and oncogenic pathways, which will facilitate the long-term goal of exploiting DNA repair and vulnerability in cancer to revolutionize treatment for cancer patients.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Training in Precision Environmental Health Sciences (TPEHS)  Appointments Title Department / School Institution Professor and Chair Experimental Radiation Oncology MD Anderson Cancer Center

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