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Faculty Profile Last Modified Time: 02:02:03 PM Fri, 27 Mar 2020   Contact Information Janice Endsley Associated Profiles  Professor, Microbiology & Immunology and Pathology, UT Medical Branch at Galveston     jjendsle@utmb.edu     (409) 772-3142    Web Link    Mycobacterium Bovis, T-Lymphocytes, Bovine Viral Diarrhea Viruses, Bovine Viral Diarrhea Virus 2, Interleukin-15, Infection, Macrophages, Tuberculosis    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   Iowa State University 2000  MS   Purdue University 1994  BS   University of Wisconsin-Platteville 1992  Research and Expertise Research Interests   My research is focused on mechanisms and regulation of cell mediated immunity to Mycobacterium tuberculosis (M.tb). We utilize human subjects, infected human lung tissue, and mouse and humanized mouse models of experimental tuberculosis (TB) for these studies. An important component of my work is investigations to determine how human immunodeficiency virus (HIV) compromises CD8+T cell and macrophage function in the host immune response to M.tb. The goal of these basic studies is to identify mechanisms whereby the CD8+T cell subset can be targeted by vaccine adjuvants and/or antigens. Additionally, I have NIH funding to develop the humanized mouse as a small animal model of HIV/M.tb co-infection. Development of this model will greatly enhance capabilities to design and screen innovative prophylactics and therapeutics for TB to use in populations with HIV-compromised immune systems. Through collaboration I have additionally extended my studies of cytotoxic lymphocytes to include natural killer cell function in infectious disease (M.tb, B. anthracis) and reproduction.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Consortium for Antimicrobial Resistance (GCC AMR) Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor Microbiology & Immunology and Pathology UT Medical Branch at Galveston

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