The goal of the May group is to make molecules of interest and utility. This goal encompasses the development of powerful synthetic methodologies as well as their application to the synthesis of complex molecules. For example, chemical transformations using transition metal catalysts that stabilize carbene and ylide-like intermediates are sought to form densely functionalized bonds of great utility to the synthetic chemist and to do so with chemo- and stereoselectivity. Furthermore, cascade reactions allow for a variety of bond forming and bond breaking events to occur in one reaction setup, thus providing significant chemical transformation with high efficiency. Target molecules, such as those shown below, are principally complex natural products that exhibit a challenging architecture and intriguing biological properties. Other targets include molecular recognition motifs for directed chemical reactions or molecular biology applications. These compounds have value for therapeutic target identification, pharmaceutical development, protein sequencing, and chemical biology.
Publications/Creative Works
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