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Faculty Profile Last Modified Time: 09:33:18 AM Wed, 1 Apr 2020   Contact Information Mark Bedford Associated Profiles  Professor, Epigenetics and Molecular Carcinogenesis, UT MD Anderson Cancer Center     Smithville, TX     MD Anderson Science Park    mtbedford@mdanderson.org     512-237-9539    Web Link    Lab Webpage    Methylation, Protein-Arginine N-Methyltransferases, Arginine, Histones, Proteins, Lysine, Post Translational Protein Processing, Histone Code    Associated Profiles Research and Expertise Appointments  Research and Expertise Research Interests   Our main focus is elucidating the biological role of arginine methylation - a modification that has been implicated in nuclear export, transcriptional control and signal transduction. We have generated targeted disruptions of the arginine methyltransferase genes in the mouse in the hope of further understanding the biological role this post-translational modification. One of the arginine methyltransferases we have knocked-out is CARM1. This enzyme associates with the p160 family of nuclear hormone receptor coactivators. Using this genetic approach we have shown the critical nature of CARM1 in estrogen responsive gene expression. Additional studies are currently underway to probe the essential role of CARM1 in estrogen-mediated transcriptional activation. My laboratory is developing molecular approaches to facilitate the study of protein-protein interactions in proteomic era. We have generated functional protein-domain microarrays and used them to identify and characterize novel protein interactions. Currently, our main focus in this regard is attempting to read the histone code. Using a combination of macro- and microarray approaches we are identifying new proteins that interact with lysine methylated histone tails. In addition, we are also using proteomic approaches to identify new substrates for enzymes such as arginine methyltransferases and kinases.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Professor Epigenetics and Molecular Carcinogenesis MD Anderson Cancer Center

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