Research in the lab focuses upon the biology of intestinal myofibroblasts (IMF), also called instetinal stromal cells.. These cells are members of a family of phenotypically-related cells that include glomerular mesangial cells, renal and pulmonary interstitial fibroblasts and hepatic and pancreatic stellate cells. Located at the interface between the epithelium and lamina propria, IMF modulate information transfer between these tissue compartments and play a pivotal role in immunology, physiology, development, and carcinogenesis of the gastrointestinal tract. These cells are likely to play an important role in the etiology of colon cancer, inflammatory bowel disease (IBD) and immune tolerance.
Publications/Creative Works
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