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Faculty Profile Last Modified Time: 07:35:38 AM Thu, 16 Apr 2020   Contact Information Jeffrey N. Myers Associated Profiles  Alando J. Ballantyne Distinguished Chair, Professor, Director of Research, Head and Neck Surgery, Director of Translational Research, Surgery, UT MD Anderson Cancer Center   MDA FCT10.6028, Room No.: Unit 1445    jmyers@mdanderson.org     713-745-2667    Web Link    Squamous Cell Carcinoma, Neoplasms, Head and Neck Neoplasms, Mouth Neoplasms, Neck, Melanoma, Epidermal Growth Factor Receptor, Neoplasm Metastasis    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The mission of the Myers lab is to alleviate the suffering due to head and neck cancers through research into the mechanisms of disease progression and translational studies of investigational therapeutics in head and neck tumor models. Our group has developed orthotopic nude mouse models of i) oral tongue cancer, ii) thyroid cancer, and iii) salivary gland cancer, and with these models we have evaluated the efficacy and in vivo mechanisms of action of investigational agents including i) natural products, ii) conventional chemotherapy and iii) molecularly targeted agents. We are currently using molecular profiling of cell lines sensitive or resistant to molecular targeted agents to determine i) biomarker profiles predictive of response and/or outcome; ii) signaling pathways that might be dys-regulated in resistant cell lines. The molecular profiling strategies that we are using include i) cDNA microarray, ii) miRNA arrays, iii) reverse phase lysate arrays and iv) cytokine and angiogenic factor profiling. Investigation using these in vivo and in vitro models have also lead to exciting work examining the role of p53 mutation in head and neck squamous cell cancer, and cutting edge research in the field of Metabolomics. We are establishing the role of metabolism in tumorgenicity and drug resistance as well as identifying metabolic targets to improve treatment for patients with head and neck cancer. We are also working with collaborators from Rice University on the optimization of drug delivery through nanovector coupling of conventional chemotherapeutic agents as well as molecularly targeted agents to i) gold nanoparticles, ii) single walled carbon nanotubes, and iii) gold nanorods. In order to further understand the mechanisms of disease progression we are analyzing genomic and metabolomic changes present in head and neck cancer cell lines and primary tumor samples. This work includes a large-scale comprehensive genomic analysis of primary tongue tumor samples. It is anticipated that through the use of these complementary approaches we will make incremental progress in identifying new treatments that will improve the survival and quality of life of patients with cancers of the head and neck region.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX  Appointments Title Department / School Institution Distinguished Chair, Professor, and Director of Research Head and Neck Surgery MD Anderson Cancer Center

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