Simmons, Paul (Faculty Profile)

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Faculty Profile

Last Modified Time: 10:33:15 AM Fri, 17 Apr 2020

Contact Information
Paul Simmons	Associated Profiles
Adjunct Professor, Institute of Molecular Medicine, UT Health Science Center at Houston


Paul.J.Simmons@uth.tmc.edu

Research and Expertise
Appointments

Research and Expertise

Research Interests

The major focus of Dr Simmons' research for many years has been to utilise the paradigm of the hematopoietic system as a model to understand the mechanisms that contribute to the extrinsic regulation of stem cells in adult organs by the tissue microenvironment (stem cell niche) in which the stem cells reside. Dr Simmons has received international recognition for his pioneering contributions to basic haemopoiesis research and has an unbroken track record of excellence in this field. Current studies in his lab focus on the characteristics and biological properties of hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC) and in defining the cell and molecular composition of the respective niches for these two stem cell populations during ontogeny and in the adult skeleton. Additional studies focus on the identification of stem cells in the adult lung as a means to develop novel cellular therapies for treatment of the many disorders that currently affect the respiratory system and the application of MSC as a cell therapy for the treatment of spinal cord injury. The laboratory makes extensive use of flow cytometry, microarray-based transcriptional profiling, the development of specific monoclonal antibodies and novel transplant assays as the means to identify and characterize stem cells in adult tissues.

Publications/Creative Works

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Appointments

Title	Department / School	Institution
Adjunct Professor	Molecular Medicine	UT Health Science Center Houston

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