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Faculty Profile Last Modified Time: 09:30:45 AM Wed, 15 Apr 2020   Contact Information Jeffrey J. Molldrem Associated Profiles  Professor and Chief, Transplantation Immunology, Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center   MDA 2SCR4.2014, Room No.: Unit 0900    jmolldre@mdanderson.org     713-563-3334    Web Link    T-Lymphocytes, T-Cells, Leukemia, Transplants, Graft Vs Host Disease, Myeloblastin, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Myeloid Leukemia    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Our laboratory is focused on understanding mechanisms of adaptive immune responses to hematopoietic antigens that are endogenously expressed in leukemia, and that are cross-presented as unique tumor-associated antigens in solid tumors such as breast cancer, lung cancer, melanoma, and others. We study basic mechanisms of antigen presentation, T cell recognition and immune tolerance in the context of anti-tumor immunity. Opportunities for tutorials may focus on basic or translational projects. Basic laboratory projects in the lab include the identification of novel antigens and antigen receptors on cancer cells, mechanisms of antigen cross-presentation, and mechanisms of T cell selection and modulation by cancer as well as how cancer cells co-evolve under the selective process of adaptive immunity. Translational laboratory projects focus on discoveries made in our laboratory and involve therapeutic agents at all stages of clinical development, including (1) development of novel immune therapeutics such as a T cell receptor-like monoclonal antibody, (2) development of gene modified T cells that are adoptively transferred into patients in the context of stem cell transplantation, and (3) cancer vaccines. Laboratory techniques include genetic cloning and expression; protein expression and purification; receptor biology; multi-parameter flow cytometry and cell sorting; confocal microscopy; monoclonal antibody development; therapeutic gene modification, expansion, and characterization of immune cells; immune monitoring; and gene expression profiling.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor & Chief Stem Cell Transplantation and Cellular Therapy MD Anderson Cancer Center

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