Mitra, Sankar (Faculty Profile)

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Faculty Profile

Last Modified Time: 01:34:49 PM Wed, 29 Mar 2023

Contact Information
Sankar Mitra	Associated Profiles
Professor, Radiation Oncology, Houston Methodist Research Institute


smitra@houstonmethodist.org Web Link Lab Webpage
PCR, Cell Culture, Gel Electrophoresis, DNA, Western Blot Analysis, Cloning, Electrophoresis, Gene Expression, SDS-PAGE, Cancer Biology, Flow Cytometry, Immunofluorescence, Immunohistochemistry, RNA, RNA Isolation, Molecular Cell Biology, Cell Signaling

Research and Expertise
Appointments

Research and Expertise

Research Interests

Working in the broad area of genome damage, its repair, and its influence in carcinogenesis and cancer therapy, Dr. Mitra has made several seminal discoveries during his tenure at Oak Ridge National Laboratory, including the characterization of the E. coli repair protein for the mutagenic DNA base O-6 methylguanine produced by mutagens and anticancer alkylating agents, the naming of the repair protein MGMT, and the cloning of human MGMT. More recently, Dr. Mitra's group characterized a new family of DNA repair proteins that they named NEILs for oxidative genome damage. The recent research focus of Dr. Mitra's group is enhancement of chemo/radiation sensitivity of tumor cells using targeted DNA repair inhibitors. After the early studies on MGMT inhibition, his current research aims to identify inhibitors for repair pathways for oxidative/radiation damage.

Publications/Creative Works

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Appointments

Title	Department / School	Institution
Professor	Radiation Oncology	The Houston Methodist Hospital Research Institute

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