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Faculty Profile Last Modified Time: 12:32:08 PM Mon, 6 Apr 2020   Contact Information Cornelis Elferink Associated Profiles  Professor, Pharmacology and Toxicology, Director, Center for Environmental Toxicology, UT Medical Branch at Galveston     coelferi@utmb.edu     (409) 772-9624    Web Link    Aryl Hydrocarbon Receptors, Dioxins, Cytochrome P-450 CYP1A1, Xenobiotics, 5-Aminolevulinate Synthetase, Cell Cycle, Liver, Proteins    Associated Profiles Research and Expertise Appointments  Research and Expertise Research Interests   The major focus of Dr. Elferink's research is the role of the aryl hydrocarbon receptor (AhR) in liver function and extra-hepatic processes affecting adiposity and glucose homeostasis. The AhR is a ligand-activated soluble transcription factor historically studied in the context of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) toxicity following DNA binding to xenobiotic response elements (XREs). TCDD toxicity however, represents a disruption of normal AhR biology that influences fundamental physiological processes underlying growth and differentiation. Dr Elferink's studies have demonstrated that AhR biology regulates transcriptional and epigenetic processes affecting hepatocyte cell cycle control, apoptosis, and the production of hepatocrines (liver-derived hormones) with systemic properties. The long-term objectives are to garner a comprehensive mechanistic understanding of AhR biology in the liver using contemporary molecular, cellular, and genome-wide methodologies in model systems. A second major research endeavor in the laboratory is focused on actively seeking to identify and develop serum biomarkers for early detection of hepatocellular carcinoma (HCC) in patients at-risk for developing liver cancer. The approach uses proteomic strategies based sophisticated separation strategies coupled with state-of-the-art mass spectrometry including multiplexed Selected Reaction Monitoring for use in validation studies. Successful development of specific and sensitive serum biomarkers for early HCC will enhance surveillance of millions who are at risk of developing HCC.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Professor Pharmacology and Toxicology UT Medical Branch at Galveston

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