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Faculty Profile Last Modified Time: 10:29:56 AM Mon, 6 Apr 2020   Contact Information Laurence J.N. Cooper Associated Profiles  Visiting Scientist, Pediatrics - Research, UT MD Anderson Cancer Center     ljncooper@mdanderson.org     (713) 563-5393    National Foundation for Cancer Research Profile    Oncology, Hematological Malignancies, Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation, Pediatric Oncology, Clinical Trials in Pediatrics, Electroporation, Immunotherapy, Methods, Gene Therapy    Associated Profiles Research and Expertise Appointments  Research and Expertise Research Interests   T-cells are part of the body's immune system that is responsible for identifying, attacking and destroying diseased cells. However, cancer cells can hide. And in order for T-cells to get rid of cancer, they first have to "see" the cancer. Dr. Cooper and his team of researchers found a way to modify the T-cells collected from a leukemia or lymphoma patient and enable them to "see" the tumor cells. The research team employed a genetic engineering technique that makes the T-cells carry a "cellular antenna" (chimeric antigen receptor or CAR), which specifically detects a molecule called CD19 that is found on the tumor cell surface of several types of leukemia and lymphoma (including Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia and Lymphomas of the B-lineage). When the CAR-T cells are fully-equipped and infused back to the same patient, they can mount full-blown immune attacks on tumor cells. In addition, since cancerous tissues often contain less oxygenated cells, Dr. Cooper is developing an approach to make the engineered CAR-T cells seek out cancer cells specifically in tissues that are less oxygenated. Preliminary laboratory results are very encouraging. Moving research to patient care, Dr. Cooper's team recently published their laboratory results from a high throughput device that rapidly makes large numbers of CAR-T cells. Although it is still early in its development, Dr. Cooper predicts the innovative device will provide a faster and safer method for redirecting immune cells.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Appointments Title Department / School Institution Visiting Scientist Pediatrics MD Anderson Cancer Center

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