Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 12:05:24 PM Mon, 6 Apr 2020   Contact Information Dean Edwards Associated Profiles  Professor, Molecular & Cellular Biology and Pathology, Executive Director, Advanced Technology Cores, Baylor College of Medicine, Associate Director, Research Infrastructure; Director, Antibody-Based Proteomics Shared Resource, Bayor College of Medicine   Mail Box: BCM130, Alkek Building for Biomedical Research, Room No.: R505    deane@bcm.edu    Web Link    Mammary Glands, Animal, Receptors, Progesterone, STAT5 Transcription Factor, Progesterone, Nuclear Receptor Coactivator 1    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Dr. Edwards' research laboratory has been funded by NIH grants for over 28 years in the areas of the biology and mechanism of action of steroid hormone receptors in normal mammary gland development and in breast cancer. Current studies include the role of progesterone as a risk factor in breast cancer through alterations of progesterone receptor (PR) signaling in early stages of breast tumorigenesis. Model systems have been developed to examine PR regulated transcriptional signaling pathways in normal mammary epithelial cells and how these pathways are dysregulated in pre-neoplastic lesions, including hyperplasias and ductal carcinoma in situ, and contribute to progression to invasive cancers. Also of interest are structure function studies of PR that have uncovered unique structural features of how coactivators interact to induce an active folded conformation of the intrinsically disordered amino terminal AF1 transcriptional activation domain. This structural information is being used for development of small molecules that interfere with PR AF1-coactivator interactions as a potential novel therapeutic target in breast cancer.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Appointments Title Department / School Institution Professor Molecular and Cellular Biology Baylor College of Medicine

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.