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Faculty Profile Last Modified Time: 11:20:27 AM Wed, 22 Apr 2020   Contact Information David Volk Associated Profiles  Associate Professor, Institute of Molecular Medicine, UT Health Science Center at Houston   Fayez S. Sarofim Research Building, Room No.: 330E    David.Volk@uth.tmc.edu     713-500-3611     713.500.0319    Web Link    Nuclear Magnetic Resonance, Viral Envelope Proteins, Proteins, Flavivirus, DNA, West Nile Virus, Dengue Virus, Nucleotide Aptamers    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   My focus is to develop cancer targeting agents using X-aptamer reagents that combine drugs or protein side-chains, along with backbone modifications on DNA, to provide directed delivery of anti-cancer medications to tumors. By conjugating them with nanoparticles, they offer the ability to provide for the slow release of anti-cancer drugs or siRNA at the tumor, thereby further reducing unwanted collateral damage to remote tissue. We have developed several X-aptamers targeting E-selectin, CD44, and annexin A2, proteins that are over-expressed on the surface of tumors or tumor associated vasculature. Recently (Mai et al. 2014), we showed that as part of a multistage vector ESTA1, our aptamer targeting E-selectin, directed anti-cancer siRNA to the bone marrow leading to significantly increased survival rates. More recently (Mangala et al, 2016) we have shown that aptamer directed delivery of siRNA improves vascular maturation thereby enhancing the anti-tumor effects of chemotherapy. A number of exciting X-aptamers are in development for use in the fight against cancer and other diseases. Another interest is developing software for the analysis of next-generation sequencing (NGS) data. We created Aptaligner for the automated analysis of X-aptamer NGS data files (Lu et al. 2014), and we are currently creating a new program to analyze antigenic variation data in Lyme disease.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn, Sr. GCC for Magnetic Resonance GCC Cluster NanoX GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Associate Professor Molecular Medicine UT Health Science Center Houston

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