My research interests are primarily focused on two areas: (1) the pharmacokinetic analysis of factors that affects bioavailability of drugs. Therapeutic agents often exhibit poor and/or variable oral bioavailability due to their physico-chemical properties and physiological factors. Using rat as an animal model, pharmacokinetic studies are designed to identify mechanisms of oral drug bioavailability and potential drug-drug interactions; (2) the pharmacogenetic analysis of anticancer therapy through integrating genetic determinants of cancer, pharmacokinetics and pharmacodynamics of anticancer drugs, and clinical outcome. Understanding genetic determinants of individual patient and their relationship with drug pharmacokinetics and clinical outcome would have a major impact on predicting drug response. Our long-term goal is to develop pharmacokinetically appropriate strategies for individualized chemotherapy and prevention.
Publications/Creative Works
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