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Faculty Profile Last Modified Time: 11:18:37 AM Thu, 16 Apr 2020   Contact Information Kevin Phillips Associated Profiles  Assistant Professor, Molecular & Cellular Biology, Academic Co-Director, Protein and Monoclonal Antibody Production Core, Baylor College of Medicine   Mail Box: BCM130, One Baylor Plaza, Room No.: BCMM-M727A    kevinp@bcm.edu     (713) 798-6946    Web Link    Lab Webpage    Energy Balance, Lipid Homeostasis, Experimental Therapeutics, Obesity, Thyroid Hormone Signaling, Metabolism, Thyroid Hormone Receptors, Metabolic Syndrome, TR Activation, Insulin Sensitivity, Fat Loss, Thermogenesis    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The Phillips lab focuses on understanding how thyroid hormone signaling regulates various aspects of metabolism. Activation of the thyroid hormone receptors (TRs) elicits catabolic processes that tend to oppose obesity and the maladies of metabolic syndrome. Our lab is interested in understanding how TR activation leads to a reduction of serum cholesterol and lipid levels, the amelioration of fatty liver disease, increased insulin sensitivity, and fat loss. We are keenly interested in understanding how TR activation mediates thermogenesis - the conversion of excess energy (such as extra calories or fat) to heat. In work that is ongoing, we have discovered a novel mechanism by which TR activation elicits thermogenesis, causing severely obese mice to lose the majority of their fat mass in about two weeks. We are currently working to identify the molecular events that mediate this effect and are exploring the potential of this action to treat obesity and metabolic disease.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Assistant Professor Molecular and Cellular Biology Baylor College of Medicine Academic Co-Director Protein and Monoclonal Antibody Production Core Baylor College of Medicine

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