Wu, Samuel Miao-Sin (Faculty Profile)

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Faculty Profile

Last Modified Time: 02:39:40 PM Fri, 17 Apr 2020

Contact Information
Samuel Miao-Sin Wu	Associated Profiles
Professor and Camille and Raymond Hankamer Chair, Opthalmology; Professor, Molecular Physiology & Biophysics, and Neuroscience, Baylor College of Medicine

NC 205
swu@bcm.tmc.edu (713) 798-5966 Web Link
Retinal Ganglion Cells, Retina, Retinal Rod Photoreceptor Cells, Retinal Cone Photoreceptor Cells, Amacrine Cells

Research and Expertise
Appointments

Research and Expertise

Research Interests

The objective of our research is to understand mechanisms underlying retinal synaptic dysfunction and cell death in glaucoma and age-related macular degeneration (AMD). We plan to use the newly developed eight-channel patch clamp recording system. This system is the most powerful electrophysiological recoding apparatus in the world, which allows recording of eight retinal cells simultaneously for studying their inter-connections and light responses in animal models of glaucoma and AMD. Dr. Wu's group will continue studying mechanisms underlying retinal dysfunction and cell death in glaucoma and AMD. His lab will develop new Eight-channel patch clamp recording system, the multi-electrode arrays and data acquisition/analysis software that allows high throughput investigation on detailed functional connectivity maps and spatiotemporal response profiles of simultaneously recorded retinal ganglion cells. They will also develop new computerized optokinetic reflex recording system to study changes in motion sensitivity of visual neurons in healthy and diseased retinas. Moreover, they will study how glaucomatous and AMD insults alter synaptic connectivity and receptive fields of various types of retinal neuron.

Publications/Creative Works

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Appointments

Title	Department / School	Institution
Professor and Camille and Raymond Hankamer Chair	Opthalmology	Baylor College of Medicine

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