Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 10:39:27 AM Tue, 7 Apr 2020   Contact Information Li-Yen Huang Associated Profiles  Professor, Neuroscience, Cell Biology, and Anatomy, UT Medical Branch at Galveston   Mail Box: 1069, Medical Research Building, Room No.: 2.143    lmhuang@utmb.edu     (409)772-1946    Web Link    Neurons, Spinal Ganglia, Batrachotoxins, Purinergic P2X3 Receptors, N-Methyl-D-Aspartate Receptors, Posterior Horn Cells, Neuroglia, Neuroblastoma    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   The research focus of this laboratory is to understand the molecular and cellular mechanisms underlying chronic pain and nociception. We have concentrated our studies on plastic changes in cell signaling following inflammation and nerve injury. Dorsal root ganglion (DRG) neurons and dorsal horn neurons in the spinal cord and in the caudal medulla play a central role in the transmission and integration of nociceptive information. Understanding the receptor channel properties of these neurons, their responses to ATP, glutamate and opioids and the involvement of G-proteins and second messenger signaling under normal and injurious conditions has led to insights into the basis of abnormal sensory information processing in injurious states. Another research focus is to understand the mechanism of ATP release between the cell body of a DRG neuron and its surrounding satellite glial cells and to determine the significance of this release, the involvement of purinergic receptors in neuron-satellite glial cell communication and changes in the communication after tissue and nerve injuries. The third interest is to determine the applicability of our knowledge of pain processing obtained in rodents to humans. Attempts to use our understanding of opioid analgesia, obtained mainly from studies of rat models, in clinical trials often failed. To address this inadequacy, we determined opioid analgesia in sheep and found that the human equivalent ceiling dose calculated from sheep is much closer to the human morphine ceiling dose than that obtained from rats. This observation emphasizes the importance of using large animal models to validate the data obtained from rodent experiments before clinical trials.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortium for Translational Pain Research  Appointments Title Department / School Institution Professor Neuroscience, Cell Biology, and Anatomy UT Medical Branch at Galveston

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.